Tzu Chi Medical Journal
Volume 20, Issue 2 , Pages 91-100, June 2008

Risk Factors and Genetic Markers of Human Papillomavirus-induced Cervical Carcinogenesis: A Focus on Chinese Populations in Southeast Asia and Southern China

  • Tang-Yuan Chu

      Affiliations

    • Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Graduate Institute of Clinical Medicine, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien, Taiwan

Received 11 September 2007; received in revised form 23 October 2007; accepted 16 November 2007.

Article Outline

Abstract 

Cervical cancer is a disease that is caused by persistent human papillomavirus (HPV) infection. The fate of this sexually transmitted infection is determined by long-term host-viral and host-environmental interactions. Given that the majority population of Han Chinese have a similarity in genetic makeup, and cultural and social systems, it is not surprising to see a common spectrum of type-or variant-specific HPV prevalence and risk for cervical cancer in Taiwan, Hong Kong and Singapore. These populations also share similar behavioral and environmental exposure risks, as well as genetic susceptibility to cervical cancer. In this post-genomic era, when the code, control and function of the human genome are being quickly unveiled, new genetic and epigenetic biomarkers for cervical cancer are emerging systemically and in an overwhelming way. This review covers the conventional epidemiological risks of HPV infection and the development of cervical cancer, as well as the emerging new molecular biomarkers, in a focused population of Chinese subjects in Southeast Asia and Southern China.

Keywords:  Cervical cancer , Chinese population , Genetic marker , Human papillomavirus

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PII: S1016-3190(08)60017-8

doi:10.1016/S1016-3190(08)60017-8

Tzu Chi Medical Journal
Volume 20, Issue 2 , Pages 91-100, June 2008

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