Tzu Chi Medical Journal
Volume 20, Issue 3 , Pages 169-176 , September 2008

Regenerative Therapy for Stress Urinary Incontinence

  • Ron Jankowski

      Affiliations

    • Cook MyoSite, Inc., Pittsburgh, PA, USA
  • ,
  • Ryan Pruchnic

      Affiliations

    • Cook MyoSite, Inc., Pittsburgh, PA, USA
  • ,
  • David Wagner

      Affiliations

    • Cook MyoSite, Inc., Pittsburgh, PA, USA
  • ,
  • Michael B. Chancellor

      Affiliations

    • Department of Urology, William Beaumont Hospital, Royal Oak, MI, USA
    • Corresponding Author InformationCorresponding author. Department of Urology, William Beaumont Hospital, 438 Medical Office Building, 3535 West 13 Mile Road, Royal Oak, MI 48073, USA

Received 2 January 2008 ,Revised 29 January 2008 ,Accepted 1 February 2008.

References 

  1. Corcos J , Beaulieu S , Donovan J , et al.   Quality of life assessment in men and women with urinary incontinence . J Urol . 2002;168:896–905
  2. Norton P , Brubaker L . Urinary incontinence in women . Lancet . 2006;367:57–67
  3. Hampel C , Wienhold D , Benken N , Eggersmann C , Thuroff JW . Prevalence and natural history of female incontinence . Eur Urol . 1997;32(Suppl 2):3–12
  4. Bump RC , Norton PA . Epidemiology and natural history of pelvic floor dysfunction . Obstet Gynecol Clin North Am . 1998;25:723–746
  5. Peschers U , Schaer G , Anthuber C , Delancey JO , Schuessler B . Changes in vesical neck mobility following vaginal delivery . Obstet Gynecol . 1996;88:1001–1006
  6. Thom DH , van den Eeden SK , Brown JS . Evaluation of parturition and other reproductive variables as risk factors for urinary incontinence in later life . Obstet Gynecol . 1997;90:983–989
  7. Meyer S , Schreyer A , De Grandi P , Hohlfeld P . The effects of birth on urinary continence mechanisms and other pelvicfloor characteristics . Obstet Gynecol . 1998;92:613–618
  8. Sampselle CM , Miller JM , Mims BL , Delancey JO , Ashton-Miller JA , Antonakos CL . Effect of pelvic muscle exercise on transient incontinence during pregnancy and after birth . Obstet Gynecol . 1998;91:406–412
  9. McGuire EJ , Lytton B , Pepe V , Kohorn EI . Stress urinary incontinence . Obstet Gynecol . 1976;47:255–264
  10. Blaivas JG . A modest proposal for the diagnosis and treatment of urinary incontinence in women . J Urol . 1987;138:597–598
  11. Kayigil O , Iftekhar Ahmed S , Metin A . The coexistence of intrinsic sphincter deficiency with type II stress incontinence . J Urol . 1999;162:1365–1366
  12. Radley SC , Chapple CR , Bryan NP , Clarke DE , Craig DA . Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: a placebocontrolled, doubleblind crossover study . Neurourol Urodyn . 2001;20:43–52
  13. Chancellor MB . Duloxetine for treatment of stress urinary incontinence . Evid Based OBGYN . 2004;6:196
  14. Herschorn S , Glazer AA . Early experience with small volume periurethral polytetrafluoroethylene for female stress urinary incontinence . J Urol . 2000;163:1838–1842
  15. Sakamoto K , Sharma S , Wheeler JS . Long-term subjective continence status and use of alternative treatments by women with stress urinary incontinence after collagen injection therapy . World J Urol . 2007;25:431–433
  16. Maher CF , O'Reilly BA , Dwyer PL , Carey MP , Cornish A , Schluter P . Pubovaginal sling versus transurethral macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial . BJOG . 2005;112:797–801
  17. Chrouser KL , Fick F , Goel A , Itano NB , Sweat SD , Lightner DJ . Carbon coated zirconium beads in betaglucan gel and bovine glutaraldehyde crosslinked collagen injections for intrinsic sphincter deficiency: continence and satisfaction after extended followup . J Urol . 2004;171:1152–1155
  18. Bent AE , Tutrone RT , McLennan MT , Lloyd LK , Kennelly MJ , Badlani G . Treatment of intrinsic sphincter deficiency using autologous ear chondrocytes as a bulking agent . Neurourol Urodyn . 2001;20:157–165
  19. Sweat SD , Lightner DJ . Complications of sterile abscess formation and pulmonary embolism following periurethral bulking agents . J Urol . 1999;161:93–96
  20. McKinney CD , Gaffey MJ , Gillenwater JY . Bladder outlet obstruction after multiple periurethral polytetrafluoroethylene injections . J Urol . 1995;153:149–151
  21. Papa Petros PE . Tissue reaction to implanted foreign materials for cure of stress incontinence . Am J Obstet Gynecol . 1994;171:1159
  22. Kiilholma PJ , Chancellor MB , Makinen J , Hirsch IH , Klemi PJ . Complications of Teflon injection for stress urinary incontinence . Neurourol Urodyn . 1993;12:131–137
  23. Lee JY , Cannon TW , Pruchnic R , Fraser MO , Huard J , Chancellor MB . The effects of periurethral musclederived stem cell injection on leak point pressure in a rat model of stress urinary incontinence . Int Urogynecol J Pelvic Floor Dysfunct . 2003;14:31–37
  24. Edwards RG . A burgeoning science of embryological genetics demands a modern ethics . Reprod Biomed Online . 2007;15(Suppl 1):34–40
  25. DeLancey JO . Structural support of the urethra as it relates to stress urinary incontinence: the hammock hypothesis . Am J Obstet Gynecol . 1994;170:1713–1723
  26. Schroder HD , Reske-Nielsen E . Fiber types in the striated urethral and anal sphincters . Acta Neuropathol . 1983;60:278–282
  27. De Groat WC . Integrative control of the lower urinary tract: preclinical perspective . Br J Pharmacol . 2006;147(Suppl 2):S25–S40
  28. Chancellor MB , Perkin H , Yoshimura N . Recent advances in the neurophysiology of stress urinary incontinence . Scand J Urol Nephrol . 2005;39:21–24
  29. Thor KB , Katofiasc MA . Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloraloseanesthetized female cat . J Pharmacol Exp Ther . 1995;274:1014–1024
  30. Kaiho Y , Kamo I , Chancellor MB , Arai Y , de Groat WC , Yoshimura N . Role of noradrenergic pathways in sneezeinduced urethral continence reflex in rats . Am J Physiol Renal Physiol . 2007;292:F639–F646
  31. Kamo I , Torimoto K , Chancellor MB , de Groat WC , Yoshimura N . Urethral closure mechanisms under sneezeinduced stress condition in rats: a new animal model for evaluation of stress urinary incontinence . Am J Physiol Regul Integr Comp Physiol . 2003;285:R356–R365
  32. Kamo I , Kaiho Y , Canon TW , et al.   Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma . J Urol . 2006;176:2711–2715
  33. De Groat WC . Anatomy of the central neural pathways controlling the lower urinary tract . Eur Urol . 1998;34(Suppl 1):2–5
  34. Kamo I , Cannon TW , Conway DA , et al.   The role of bladdertourethral reflexes in urinary continence mechanisms in rats . Am J Physiol Renal Physiol . 2004;287:F434–F441
  35. Strasser H , Ninkovic M , Hess M , Bartsah G , Stenzl A . Anatomic and functional studies of the male and female urethral sphincter . World J Urol . 2000;18:324–329
  36. Strasser H , Tiefenthaler M , Steinlechner M , Eder I , Bartsch G , Konwalinka G . Age dependent apoptosis and loss of rhabdosphincter cells . J Urol . 2000;164:1781–1785
  37. Pittenger MF , Mackay AM , Beck SC , et al.   Multilineage potential of adult human mesenchymal stem cells . Science . 1999;284:143–147
  38. Ferrari G , Cusella-De Angelis G , Coletta M , et al.   Muscle regeneration by bone marrowderived myogenic progenitors . Science . 1998;279:1528–1530
  39. Prockop DJ . Marrow stromal cells as stem cells for nonhematopoietic tissues . Science . 1997;276:71–74
  40. Dezawa M , Ishikawa H , Itokazu Y , et al.   Bone marrow stromal cells generate muscle cells and repair muscle degeneration . Science . 2005;309:314–317
  41. Qu Z , Balkir L , van Deutekom JC , Robbins PD . Development of approaches to improve cell survival in myoblast transfer therapy . J Cell Biol . 1998;142:1257–1267
  42. Seale P , Asakura A , Rudnicki MA . The potential of muscle stem cells . Dev Cell . 2001;1:333–342
  43. Jankowski RJ , Deasy BM , Huard J . Muscle-derived stem cells . Gene Ther . 2002;9:642–647
  44. Oshima H , Payne TR , Urish KL , et al.   Differential myocardial infarct repair with muscle stem cells compared to myoblasts . Mol Ther . 2005;12:1130–1141
  45. Lee JY , Qu-Petersen Z , Cao B , et al.   Clonal isolation of musclederived cells capable of enhancing muscle regeneration and bone healing . J Cell Biol . 2000;150:1085–1100
  46. Qu-Petersen Z , Deasy B , Jankowski R , et al.   Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration . J Cell Biol . 2002;157:851–864
  47. Yokoyama T , Yoshimura N , Dhir R , et al.   Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence . J Urol . 2001;165:271–276
  48. Lee JY , Paik SY , Yuk SH , Lee JH , Ghil SH , Lee SS . Long term effects of musclederived stem cells on leak point pressure and closing pressure in rats with transected pudendal nerves . Mol Cells . 2004;18:309–313
  49. Kwon D , Kim Y , Pruchnic R , et al.   Periurethral cellular injection: comparison of musclederived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence . Urology . 2006;68:449–454
  50. Chancellor MB , Yokoyama T , Tirney S , et al.   Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility . Neurourol Urodyn . 2000;19:279–287
  51. Yokoyama T , Pruchnic R , Lee JY , et al.   Autologous primary musclederived cells transfer into the lower urinary tract . Tissue Eng . 2001;7:395–404
  52. Huard J , Yokoyama T , Pruchnic R , et al.   Muscle-derived cellmediated ex vivo gene therapy for urological dysfunction . Gene Ther . 2002;9:1617–1626
  53. Cannon TW , Lee JY , Somogyi G , et al.   Improved sphincter contractility after allogenic musclederived progenitor cell injection into the denervated rat urethra . Urology . 2003;62:958–963
  54. Chermansky CJ , Tarin T , Kwon DD , et al.   Intraurethral musclederived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency . Urology . 2004;63:780–785
  55. Beckingham IJ , Wemyss-Holden G , Lawrence WT . Long-term followup of women treated with perurethral Teflon injections for stress incontinence . Br J Urol . 1992;69:580–583
  56. Zuk PA , Zhu M , Mizuno H , et al.   Multilineage cells from human adipose tissue: implications for cellbased therapies . Tissue Eng . 2001;7:211–228
  57. Rodriguez LV , Alfonso Z , Zhang R , Leung J , Wu B , Ignarro LJ . Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells . Proc Natl Acad Sci USA . 2006;103:12167–12172
  58. Jack GS , Almeida FG , Zhang R , Alfonso ZC , Zuk PA , Rodriguez LV . Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction . J Urol . 2005;174:2041–2045
  59. Zeng X , Jack GS , Zhang R , et al.   Treatment of SUI using adipose derived stem cells: restoration of urethral function . J Urol . 2006;175:291
  60. Robbins SG , Rajaratnam VS , Penn JS . Evidence for upregulation and redistribution of vascular endothelial growth factor (VEGF) receptors flt-1 and flk-1 in the oxygeninjured rat retina . Growth Factors . 1998;16:1–9
  61. Florini JR , Ewton DZ , Magri KA . Hormones, growth factors, and myogenic differentiation . Annu Rev Physiol . 1991;53:201–216
  62. Ruberti F , Capsoni S , Comparini A , et al.   Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy . J Neurosci . 2000;20:2589–2601
  63. Rende M , Brizi E , Conner J , et al.   Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA . Int J Dev Neurosci . 2000;18:869–885
  64. Reddypalli S , Roll K , Lee HK , Lundell M , Barea-Rodriguez E , Wheeler EF . p75NTR-mediated signaling promotes the survival of myoblasts and influences muscle strength . J Cell Physiol . 2005;204:819–829
  65. Wheeler EF , Gong H , Grimes R , Benoit D , Vazguez L . p75NTR and Trk receptors are expressed in reciprocal patterns in a wide variety of nonneural tissues during rat embryonic development, indicating independent receptor functions . J Comp Neurol . 1998;391:407–428
  66. Dedkov EI , Kostrominova TY , Borisov AB , Carlson BM . Survival of Schwann cells in chronically denervated skeletal muscles . Acta Neuropathol . 2002;103:565–574
  67. Shooter EM . Early days of the nerve growth factor proteins . Annu Rev Neurosci . 2001;24:601–629
  68. Shi H , Song CK , Giordano A , Cinti S , Bartness TJ . Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity . Am J Physiol Regul Integr Comp Physiol . 2005;288:R1028–R1037
  69. Peeraully MR , Jenkins JR , Trayhurn P . NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines . Am J Physiol Endocrinol Metab . 2004;287:E331–E339
  70. Strasser H , Marksteiner R , Margreiter E , et al.   Transurethral ultrasonographyguided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence . World J Urol . 2007;25:385–392
  71. Strasser H , Pinggera GM , Gozzi C , et al.   Three-dimensional transrectal ultrasound of the male urethral rhabdosphincter . World J Urol . 2004;22:335–338
  72. Strasser H , Marksteiner R , Margreiter E , et al.   Autologous myoblasts and fibroblasts versus collagen for treatment of stress urinary incontinence in women: a randomised controlled trial . Lancet . 2007;369:2179–2186
  73. Mitterberger M , Pinggera GM , Marksteiner R , et al.   Adult stem cell therapy of female stress urinary incontinence . Eur Urol . 2007;53:169–175
  74. Carr LK , Steele D , Steele S , et al.   1-year follow up of autologous musclederived stem cell injection pilot study to treat stress urinary incontinence . Int Urogynecol J Pelvic Floor Dysfunct . 2008;19:881–883
  75. Ulmsten U , Johnson P , Rezapour M . A threeyear follow up of tension free vaginal tape for surgical treatment of female stress urinary incontinence . Br J Obstet Gynaecol . 1999;106:345–350
  76. Nilsson CG , Kuuva N , Falconer C , Rezapour M , Ulmsten U . Long-term results of the tensionfree vaginal tape (TVT) procedure for surgical treatment of female stress urinary incontinence . Int Urogynecol J Pelvic Floor Dysfunct . 2001;12(Suppl 2):S5–S8
  77. Jeffry L , Deval B , Birsan A , Soriano D , Darai E . Objective and subjective cure rates after tensionfree vaginal tape for treatment of urinary incontinence . Urology . 2001;58:702–706
  78. Ward KL , Hilton P . A prospective multicenter randomized trial of tensionfree vaginal tape and colposuspension for primary urodynamic stress incontinence: twoyear follow-up . Am J Obstet Gynecol . 2004;190:324–331

PII: S1016-3190(08)60032-4

doi: 10.1016/S1016-3190(08)60032-4

Tzu Chi Medical Journal
Volume 20, Issue 3 , Pages 169-176 , September 2008