Tzu Chi Medical Journal
Volume 20, Issue 4 , Pages 253-269 , December 2008

Clinical Applications and Usefulness of Integrated Single Photon Emission Computed Tomography/Computed Tomography Imaging

  • Pan-Fu Kao

      Affiliations

    • Department of Nuclear Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    • Department of Radiological Technology, Tzu Chi College of Technology, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Nuclear Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, 289, Jianguo Road, Xindian City, Taipei, Taiwan
  • ,
  • Yu-Hsiang Chou

      Affiliations

    • Department of Nuclear Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan

Received 31 March 2008 ,Revised 14 April 2008 ,Accepted 1 May 2008.

References 

  1. von Schulthess G . Introduction . In:  von Schulthess G editors. Molecular Anatomic Imaging: PET-CT and SPECT-CT Integrated Modality Imaging . 2nd ed.. Philadelphia: Lippincott Williams & Wilkins; 2007;p. 3–9
  2. Bocher M , Balan A , Krausz Y , et al.   Gamma camera-mounted anatomical X-ray tomography: technology, system characteristics and first images . Eur J Nucl Med . 2000;27:619–627
  3. O'Connor MK , Kemp BJ . Single photon emission computed tomography/computed tomography: basic instrumentation and innovations . Semin Nucl Med . 2006;36:258–266
  4. Hasagawa BH , Stebler B , Rutt BK . A prototype high-purity germanium detector system with fast photon counting circuitry for medical imaging . Med Phys . 1991;18:900–999
  5. Lang TF , Hasagawa BH , Liew SC , et al.   Description of a prototype emission transmission computed tomography imaging system . J Nucl Med . 1992;33:1881–1887
  6. Kalki K , Blankespoor SC , Brown JK , et al.   Myocardial perfusion imaging with a combined x-ray CT and SPECT system . J Nucl Med . 1997;38:1535–1540
  7. Tang HR , Da Silva AJ , Matthay KK , et al.   Neuroblastoma imaging using a combined CT scanner–scintillation camera and 131I-MIBG . J Nucl Med . 2001;42:237–247
  8. King MA , Tsui BM , Pan TS , Glick SJ , Soares EJ . Attenuation compensation for cardiac single-photon emission computed tomographic imaging: part 2. Attenuation compensation algorithms . J Nucl Cardiol . 1996;3:55–64
  9. Hutton BF , Hudson HM , Beekman FJ . A clinical perspective of accelerated statistical reconstruction . Eur J Nucl Med . 1997;24:797–808
  10. Love C , Palestro CJ . Radionuclide imaging of infection . J Nucl Med Technol . 2004;32:47–57
  11. De Winter F , Gemmel F , Van Laere K , et al.   99mTcciprofloxacin planar and tomographic imaging for the diagnosis of infection in the postoperative spine: experience in 48 patients . Eur J Nucl Med Mol Imaging . 2004;31:233–239
  12. Yapar Z , Kibar M , Yapar AF , Togrul E , Kayaselcuk U , Sarpel Y . The efficacy of technetium-99m ciprofloxacin (infection) imaging in suspected orthopaedic infection: a comparison with sequential bone/gallium imaging . Eur J Nucl Med . 2001;28:822–830
  13. Bleeker-Rovers CP , Vos FJ , Wanten GJ , et al.   18F-FDG PET in detecting metastatic infectious disease . J Nucl Med . 2005;46:2014–2019
  14. Love C , Tomas MB , Tronco GG , Palestrol CJ . FDG PET of infection and inflammation . Radiographics . 2005;25:1357–1368
  15. Hoffer P . Gallium: mechanisms . J Nucl Med . 1980;21:282–285
  16. Newman RD , McAfee JG . Gallium-67 imaging in infection . In:  Sandler MP ,  Coleman RE ,  Patton JA editor. Diagnostic Nuclear Medicine . 4th ed.. Philadelphia: Lippincott, Williams & Wilkins; 2004;p. 1205–1217
  17. Kao PF , Tsui KH , Leu HS , Tsai MF , Tzen KY . Diagnosis and treatment of pyogenic psoas abscess in diabetic patients: usefulness of computed tomography and gallium-67 scanning . Urology . 2001;57:246–251
  18. Kao PF , Tzen KY , Tsui KH , Tsai MF , Yen TC . The specific gallium-67 scan uptake pattern in psoas abscesses . Eur J Nucl Med . 1998;25:1442–1447
  19. Kao PF , Chen KS , Tsai MF , Ng SH , Tzen KY . Repeated gallium-67 scan demonstrating an occult mycotic aneurysm of the aortic arch due to Salmonella . Scand J Infect Dis . 2003;35:199–202
  20. Tzen KY , Yen TC , Yang RS , Lee CM , Kao PF , Lin KJ . The role of 67Ga in the early detection of spinal epidural abscesses . Nucl Med Commun . 2000;21:165–170
  21. Kao PF , Tzen KY , Tsai MF , Chen FP . Pyometra as a lower abdominal doughnut sign on a Ga-67 scan . Clin Nucl Med . 2000;25:485–486
  22. Kao PF , Tzen KY , Tsai MF , Yang KJ . Gallium-67 scanning in endogenous Klebsiella endophthalmitis with unknown primary focus . Scand J Infect Dis . 2000;32:326–328
  23. Swayne LC . Computer-assisted fusion of single-photon emission tomographic and computed tomographic images. Evaluation in complicated inflammatory disease . Invest Radiol . 1992;27:78–83
  24. Bar-Shalom R , Yefremov N , Guralnik L , et al.   SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection . J Nucl Med . 2006;47:587–594
  25. Kao PF , Huang MJ , You DL , Tzen KY . Using 131I MIBG and 99mTC-MDP bone scan for localization of rare extra-adrenal pheochromocytomas: report of 2 cases . J Formos Med Assoc . 1992;91(Suppl 4):S283–S287
  26. Kao PF , Tzen KY , Huang MJ , You DL . Obstructive hydronephrosis with I-131 MIBG accumulation mimicking huge pheochromocytoma: a diagnosis pitfall found with Tc-99m MDP imaging . Clin Nucl Med . 1996;21:994–995
  27. Kao PF , Chang HY , Tsai MF , Lin KJ , Tzen KY , Chang CN . Breast uptake of iodine-131 mimicking lung metastases in a thyroid cancer patient with a pituitary tumour . Br J Radiol . 2001;74:378–381
  28. Leitha T , Staudenherz A . Frequency of diagnostic dilemmas in 131I whole body scanning . Nuklearmedizin . 2003;42:55–62
  29. Krausz Y , Klein M , Uziely B , et al.   Impact of SPECT/CT on assessment of I-131 avid sites in differentiated thyroid cancer . J Nucl Med . 2004;45:349
  30. Ruf J , Lehmkuhl L , Bertram H , et al.   Impact of SPECT and integrated low-dose CT after radioiodine therapy on the management of patients with thyroid carcinoma . Nucl Med Commun . 2004;25:1177–1182
  31. Tharp K , Israel O , Hausmann J , et al.   Impact of 131I-SPECT/CT images obtained with an integrated system in the followup of patients with thyroid carcinoma . Eur J Nucl Med Mol Imaging . 2004;31:1435–1442
  32. O'Doherty MJ , Kettle AG , Wells P , Collins RE , Coakley AJ . Parathyroid imaging with technetium 99m-sestamibe: preoperative localization and tissue uptake studies . J Nucl Med . 1992;33:313–318
  33. Takebayashi S , Hidai H , Chiba T , Takaga Y , Nagatani Y , Matsubara S . Hyperfunctional parathyroid glands with 99mTC-MIBI scan: semi-quantitative analysis correlated with histologic findings . J Nucl Med . 1999;40:1792–1797
  34. Ohshima A , Simizu S , Okido M , Shimada K , Kuroki S , Tanaka M . Endoscopic neck surgery: current status for thyroid and parathyroid diseases . Biomed Pharmacother . 2002;56:48s–52s
  35. Medrano C , Hazelrigg SR , Landreneau RJ , Boley TM , Shawgo T , Grasch A . Thoracoscopic resection of ectopic parathyroid glands . Ann Thorac Surg . 2000;69:221–223
  36. Denham DW , Norman J . Cost-effectiveness of preoperative sestamibi scan for primary hyperparathyroidism is dependent solely upon the surgeon's choice of operative procedure . J Am Coll Surg . 1998;186:293–305
  37. Gotthardt M , Lohmann B , Behr TM , et al.   Clinical value of parathyroid scintigraphy with technetium-99m methoxyisobutylisonitrile: discrepancies in clinical data and a systematic meta-analysis of the literature . World J Surg . 2004;28:100–107
  38. Lumachi F , Ermani M , Basso S , Zucchetta P , Borsato N , Favia G . Localization of parathyroid tumors in the minimally invasive era: which technique should be chosen? Populationbased analysis of 253 patients undergoing parathyroidectomy and factors affecting parathyroid gland detection . Endocr Relat Cancer . 2001;8:63–69
  39. Lorberboym M , Minski I , Macadziob S , Nikolor G , Schachter P . Incremental diagnostic value of preoperative 99mTc-MIBI SPECT in patients with a parathyroid adenoma . J Nucl Med . 2003;44:904–908
  40. Gayed IW , Kim EE , Broussard WF , et al.   The value of 99mTcsestamibi SPECT/CT over conventional SPECT in the evaluation of parathyroid adenomas or hyperplasia . J Nucl Med . 2005;46:248–252
  41. Krausz Y , Bettman L , Guralnik L , et al.   Technetium-99m-MIBI SPECT/CT in primary hyperparathyroidism . World J Surg . 2006;30:76–83
  42. Schillaci O , Filippi L , Danieli R , Simonetti G . Single-photon emission computed tomography/computed tomography in abdominal diseases . Semin Nucl Med . 2007;37:48–61
  43. Choi BY , Nguyen HM . The diagnosis and management of benign hepatic tumors . J Clin Gastroenterol . 2005;39:401–412
  44. Royal HD , Brown ML , Drum DE , Nagle CE , Sylvester JM , Ziessman HA . Procedure guideline for hepatic and splenic imaging. Society of Nuclear Medicine . J Nucl Med . 1998;39:1114–1116
  45. Ziessman HA , Silverman PM , Patterson J , et al.   Improved detection of small cavernous hemangiomas of the liver with high-resolution three-headed SPECT . J Nucl Med . 1991;32:2086–2091
  46. Birnbaum BA , Noz ME , Chapnick J , et al.   Hepatic hemangiomas: diagnosis with fusion of MR, CT, and Tc-99mlabeled red blood cell SPECT images . Radiology . 1991;181:469–474
  47. Schillaci O , Danieli R , Manni C , Capoccetti F , Simonetti G . Technetium-99m-labelled red blood cell imaging in the diagnosis of hepatic hemangiomas: the role of SPECT/CT with a hybrid camera . Eur J Nucl Med Mol Imaging . 2004;31:1011–1015
  48. Zheng JG , Yao ZM , Shu CY , Zhang Y , Zhang X . Role of SPECT/CT in diagnosis of hepatic hemangiomas . World J Gastroenterol . 2005;11:5336–5341
  49. Castellani M , Cappellini MD , Cappelletti M , et al.   Tc-99m sulphur colloid scintigraphy in the assessment of residual splenic tissue after splenectomy . Clin Radiol . 2001;56:596–598
  50. Gunes I , Yilmazlar T , Sarikaya I , Akbunar T , Irgil C . Scintigraphic detection of splenosis: superiority of tomographic selective spleen scintigraphy . Clin Radiol . 1994;49:115–117
  51. Horger M , Eschmann SM , Lengerke C , Claussen CD , Pfannenberg C , Bares R . Improved detection of splenosis in patients with haematological disorders: the role of combined transmission-emission tomography . Eur J Nucl Med Mol Imaging . 2003;30:316–319
  52. Valdes Olmos RA , Horenblas S , Kartachova M , Hoefnagel CA , Sivro F , Baars PC . 99mTc-labelled heat-denatured erythrocyte SPECT-CT matching to differentiate accessory spleen from tumour recurrence . Eur J Nucl Med Mol Imaging . 2004;31:150
  53. Howart DM . The role of nuclear medicine in the detection of acute gastrointestinal bleeding . Semin Nucl Med . 2006;36:133–146
  54. Yama N , Ezoe E , Kimura Y , et al.   Localization of intestinal bleeding using a fusion of Tc-99m-labeled RBC SPECT and X-ray CT . Clin Nucl Med . 2005;30:488–489
  55. Krag DN , Weaver DL , Alex JC , Fairbank JT . Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe . Surg Oncol . 1993;2:335–340
  56. Liu SH , Chang WC , Kao PF , et al.   Lymphoscintigraphy and intraoperative gamma probe-directed sentinel lymph node mapping in patients with malignant melanoma . J Formos Med Assoc . 2004;103:41–46
  57. Chetty U , Jack W , Prescott RJ , Tyler C , Rodger A . Management of the axilla in operable breast cancer treated by breast conservation: a randomized clinical trial. Edinburgh Breast Unit . Br J Surg . 2000;87:163–169
  58. Schrenk P , Rieger R , Shamiyeh A , Wayand W . Morbidity following sentinel lymph node biopsy versus axillary lymph node dissection for patients with breast carcinoma . Cancer . 2000;88:608–614
  59. Husarik DB , Fehr M , Thuerl CM , et al.   Sentinel lymph node scintigraphy in breast cancer: incremental value of SPECT/CT imaging . J Nucl Med . 2005;46:197
  60. Husarik DB , Steinert HC . Single-photon emission computed tomography/computed tomography for sentinel node mapping in breast cancer . Semin Nucl Med . 2007;37:29–33
  61. Lerman H , Metser U , Lievshitz G , Sperber F , Shneebaum S , Even-Sapir E . Lymphoscintigraphic sentinel node identification in patients with breast cancer: the role of SPECT/CT . Eur J Nucl Med Mol Imaging . 2006;33:329–337
  62. van der Ploeg IMC , Valdes Olmos RA , Nieweg OE , Rutgers EJT , Kroon BBR , Hoefnagel CA . The additional value of SPECT/CT in lymphatic mapping in breast cancer and melanoma . J Nucl Med . 2007;48:1756–1760
  63. Huang JY, Kao PF, Chen YS. Visual Enhancement for Sentinel Lymph Node Mapping in Breast Cancer by Multiple Display Formats of SPECT/CT Images. The International Conference on Bio Medical Engineering and Informatics (BMEI2008), Hainan, China, 2008.
  64. Kao PF, Huang JY, Chen YS. SLN SPECT/CT 3D Display with Bone Co-registration. The Society of Nuclear Medicine 55th Annual Meeting, New Orleans, Louisiana, USA, 2008.
  65. Horger M , Bares R . The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease . Semin Nucl Med . 2006;36:286–294
  66. Even-Sapir E . Imaging of malignant bone involvement by morphologic, scintigraphic, and hybrid modalities . J Nucl Med . 2005;46:1356–1367
  67. Kao PF , Tzen KY , Chen JY , Lin KJ , Tsai MF , Yen TC . Rectus abdominis rhabdomyolysis after sit ups: unexpected detection by bone scan . Br J Sport Med . 1998;32:253–254
  68. Kao PF , Tzen KY , Chang LY , You DL , Yang JY . 99mTc-MDP scintigraphy in high-voltage electrical burn patients . Nucl Med Commun . 1997;18:846–852
  69. Ergun EL , Kiratli PO , Gunay EC , Erbas B . A report on the incidence of intestinal 99mTc-methylene diphosphonate uptake of bone scans and a review of the literature . Nucl Med Commun . 2006;27:877–885
  70. Loutfi I , Collier BD , Mohammed AM . Nonosseous abnormalities on bone scans . J Nucl Med Technol . 2003;31:149–153
  71. Love C , Din AS , Tomas MB , Kalapparambath TP , Palestro CJ . Radionuclide bone imaging: an illustrative review . Radiographics . 2003;23:341–358

PII: S1016-3190(08)60048-8

doi: 10.1016/S1016-3190(08)60048-8

Tzu Chi Medical Journal
Volume 20, Issue 4 , Pages 253-269 , December 2008