Tzu Chi Medical Journal
Volume 21, Issue 1 , Pages 1-5 , March 2009

Nitrergic Control of Cerebral Vascular Tone and Blood Flow, and a Possible Blood–Brain Barrier Function

Received 15 October 2008 ,Revised 20 November 2008 ,Accepted 1 December 2008.

References 

  1. Toda N . Non-adrenergic, non-cholinergic innervation in monkey and human cerebral arteries . Br J Pharmacol . 1981;72:281–283
  2. Feelisch M , te Poel M , Zamora R , Deussen A , Moncada S . Understanding the controversy over the identity of EDRF . Nature . 1994;368:62–65
  3. Okamura T , Fujioka H , Ayajiki K , Toda N . Modifications by superoxide-generating agent, neurotransmitters and neuromodulators of nitroxidergic nerve function in monkey cerebral arteries . J Pharmacol Exp Ther . 1998;286:1321–1325
  4. Toda N , Okamura T . Nitroxidergic nerve: regulation of vascular tone and blood flow in the brain . J Hypertens . 1996;14:423–434
  5. Toda N , Okamura T . Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries . Jpn J Pharmacol . 1990;52:170–173
  6. Toda N , Okamura T . Mechanism underlying the response to vasodilator nerve stimulation in isolated dog and monkey cerebral arteries . Am J Physiol . 1990;259:H1511–H1517
  7. Toda N , Ayajiki K , Yoshida K , Kimura H , Okamura T . Impairment by damage of the pterygopalatine ganglion of nitrox-idergic vasodilator nerve function in canine cerebral and retinal arteries . Circ Res . 1993;72:206–213
  8. Dawson TM , Bredt DS , Fotuhi M , Hwang PM , Snyder SH . Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues . Proc Natl Acad Sci USA . 1991;88:7797–7801
  9. Nozaki K , Moskowitz MA , Maynard KI , et al.   Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries . J Cereb Blood Flow Metab . 1993;13:70–79
  10. Toda N , Ayajiki K , Tanaka T , Okamura T . Preganglionic and postganglionic neurons responsible for cerebral vasodilation mediated by nitric oxide in anesthetized dogs . J Cereb Blood Flow Metab . 2000;20:700–708
  11. Toda N , Tanaka T , Ayajiki K , Okamura T . Cerebral vasodil-atation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys . Neuroscience . 2000;96:393–398
  12. Ayajiki K , Fujioka H , Shinozaki K , Okamura T . Effects of capsaicin and nitric oxide synthase inhibitor on increase in cere bral blood flow induced by sensory and parasym-pathetic nerve stimulation in the rat . J Appl Physiol . 2005;98:1792–1798
  13. Toda N , Okamura T . The pharmacology of nitric oxide in the peripheral nervous system of blood vessels . Pharmacol Rev . 2003;55:271–324
  14. Yarnitsky D , Gross Y , Lorian A , et al.   Blood-brain barrier opened by stimulation of the parasympathetic sphenopala-tine ganglion: a new method for macromolecule delivery to the brain . J Neurosurg . 2004;101:303–309
  15. Yarnitsky D , Gross Y , Lorian A , et al.   Increased BBB permeability by parasympathetic sphenopalatine ganglion stimulation in dogs . Brain Res . 2004;1018:236–240
  16. Fellner F , Lungenschmid K , Fellner C , Bohm-Jurkovic H , Bautz W . Experiences with gadodiamide, a non-ionic contrast agent, in MRI of brain metastases . Rontgenpraxis . 1998;51:203–211
  17. Koketsu N , Moskowitz MA , Kontos HA , Yokota M , Shimizu T . Chronic parasympathetic sectioning decreases regional cerebral blood flow during hemorrhagic hypotension and increases infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats . J Cereb Blood Flow Metab . 1992;12:613–620
  18. Dalkara T , Yoshida T , Irikura K , Moskowitz MA . Dual role of nitric oxide in focal cerebral ischemia . Neuropharmacology . 1994;33:1447–1452
  19. Saito A , Handa J , Toda N . Reactivity to vasoactive agents of canine basilar arteries exposed to experimental sub-arachnoid hemorrhage . Surg Neurol . 1991;35:461–467
  20. Toda N , Kawakami M , Yoshida K . Constrictor action of oxy-hemoglobin in monkey and dog basilar arteries in vivo and in vitro . Am J Physiol . 1991;260:H420–H425
  21. Toda N , Ayajiki K , Okamura T . Neural mechanism underlying basilar arterial constriction by intracisternal L-NNA in anesthetized dogs . Am J Physiol . 1993;265:H103–H107
  22. Okamura T , Ayajiki K , Toda N . Basilar arterial constriction caused by intracisternal NG-nitro-L-arginine in anesthetized monkeys . Cardiovasc Res . 1995;30:663–667
  23. Pluta RM , Dejam A , Grimes G , Gladwin MT , Oldfield EH . Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage . JAMA . 2005;293:1477–1484
  24. Iversen HK , Olesen J , Tfelt-Hansen P . Intravenous nitro-glycerin as an experimental model of vascular headache. Basic characteristics . Pain . 1989;38:17–24
  25. Lassen LH , Ashina M , Christiansen I , Ulrich V , Olesen J . Nitric oxide synthase inhibition in migraine . Lancet . 1997;349:401–402
  26. Ayajiki K , Fujioka H , Noda K , Okamura T , Toda N . Modifications by sumatriptan and acetylcholine of nitric oxide-mediated neurogenic dilatation in dog cerebral arteries . Eur J Pharmacol . 2001;420:67–72
  27. Ayajiki K , Okamura T , Toda N . Flunarizine, an anti-migraine agent, impairs nitroxidergic nerve function in cerebral arteries . Eur J Pharmacol . 1997;329:49–53
  28. Sanders M , Zuurmond WW . Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: a 12- to 70-month follow-up evaluation . J Neurosurg . 1997;87:876–880
  29. Toda N . Nitroxidergic nerve in cranial arteries . In:  Olesen J ,  Edvinsson L editor. Headache Pathogenesis: Monoamines, Neuropeptides, Purines and Nitric Oxide . Philadelphia: Lippincott-Raven; 1997;p. 241–245

PII: S1016-3190(09)60001-X

doi: 10.1016/S1016-3190(09)60001-X

Tzu Chi Medical Journal
Volume 21, Issue 1 , Pages 1-5 , March 2009

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