Tzu Chi Medical Journal
Volume 21, Issue 1 , Pages 28-33 , March 2009

Cysteinyl Leukotriene Receptor Type 1 (CysLT1) Mediates Contraction of the Guinea Pig Lower Esophageal Sphincter

  • Shih-Che Huang

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien, Taiwan

Received 30 May 2008 ,Revised 2 June 2008 ,Accepted 15 July 2008.

References 

  1. Brink C , Dahlen SE , Drazen J , et al.   International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors . Pharmacol Rev . 2003;55:195–227
  2. Kanaoka Y , Boyce JA . Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses . J Immunol . 2004;173:1503–1510
  3. Capra V . Molecular and functional aspects of human cystei-nyl leukotriene receptors . Pharmacol Res . 2004;50:1–11
  4. Back M . Functional characteristics of cysteinyl-leukotriene receptor subtypes . Life Sci . 2002;71:611–622
  5. Fleisch JH , Rinkema LE , Baker SR . Evidence for multiple leukotriene D4 receptors in smooth muscle . Life Sci . 1982;31:577–581
  6. Lynch KR , O'Neill GP , Liu Q , et al.   Characterization of the human cysteinyl leukotriene CysLT1 receptor . Nature . 1999;399:789–793
  7. Sarau HM , Ames RS , Chambers J , et al.   Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor . Mol Pharmacol . 1999;56:657–663
  8. Takasaki J , Kamohara M , Matsumoto M , et al.   The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor . Biochem Biophys Res Commun . 2000;274:316–322
  9. Nothacker HP , Wang Z , Zhu Y , Reinscheid RK , Lin SH , Civelli O . Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist . Mol Pharmacol . 2000;58:1601–1608
  10. Snyder DW , Krell RD . Pharmacology of peptide leukotrienes on ferret isolated airway smooth muscle . Prostaglandins . 1986;32:189–200
  11. Yokomizo T , Kato K , Terawaki K , Izumi T , Shimizu T . A second leukotriene B4 receptor, BLT2. A new target in inflammation and immunological disorders . J Exp Med . 2000;192:421–432
  12. Bäck M , Jonsson EW , Dahlén SE . The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum . Eur J Pharmacol . 1996;317:107–113
  13. Heise CE , O'Dowd BF , Figueroa DJ , et al.   Characterization of the human cysteinyl leukotriene 2 receptor . J Biol Chem . 2000;275:30531–30536
  14. Ohd JF , Nielsen CK , Campbell J , Landberg G , Lofberg H , Sjolander A . Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas . Gastroenterology . 2003;124:57–70
  15. Attwood SE , Lewis CJ , Bronder CS , Morris CD , Armstrong GR , Whittam J . Eosinophilic oesophagitis: a novel treatment using Montelukast . Gut . 2003;52:181–185
  16. Arora AS , Yamazaki K . Eosinophilic esophagitis: asthma of the esophagus? . Clin Gastroenterol Hepatol . 2004;2:523–530
  17. Khan S . Eosinophilic gastroenteritis . Best Pract Res Clin Gastroenterol . 2005;19:177–198
  18. Falcone RC , Krell RD . Guinea pig gall bladder contains a single peptide leukotriene receptor which resembles that present in human conducting airway smooth muscle . J Pharmacol Exp Ther . 1992;262:1095–1102
  19. Freedman SM , Wallace JL , Shaffer EA . Characterization of leukotriene-induced contraction of the guinea-pig gallbladder in vitro . Can J Physiol Pharmacol . 1993;71:145–150
  20. Kim N , Cao W , Song IS , et al.   Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle . Gastroenterology . 1998;115:919–928
  21. Ieiri S , Nishimura J , Hirano K , Suita S , Kanaide H . The mechanism for the contraction induced by leukotriene C4 in guinea-pig taenia coli . Br J Pharmacol . 2001;133:529–538
  22. Goldenberg MM , Subers EM . The effect of leukotriene D4 on the isolated stomach and colon of the rat . Life Sci . 1983;33:2121–2127
  23. Huang SC . Endothelin receptors in lower esophageal sphincter circular smooth muscle . Regul Pept . 2005;127:27–35
  24. Huang SC . Protease-activated receptor-1 (PAR1) and PAR2 but not PAR4 mediate relaxations in lower esophageal sphincter . Regul Pept . 2007;142:37–43
  25. Bäck M , Kumlin M , Cotgreave IA , Dahlén SE . An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea . Br J Pharmacol . 2001;133:1134–1144
  26. Nurko S , Rosen R . Esophageal dysmotility in patients who have eosinophilic esophagitis . Gastrointest Endosc Clin N Am . 2008;18:73–89

PII: S1016-3190(09)60005-7

doi: 10.1016/S1016-3190(09)60005-7

Tzu Chi Medical Journal
Volume 21, Issue 1 , Pages 28-33 , March 2009

Article Tools