Tzu Chi Medical Journal
Volume 21, Issue 2 , Pages 99-102, June 2009

Neuropeptides and the Central Neural Regulation of the Cardiorespiratory System

  • Paul M. Pilowsky

      Affiliations

    • Corresponding Author InformationCorresponding author. Australian School of Advanced Medicine, Dow Corning Building, Level 1, 3 Innovation Road, Macquarie University, 2109, NSW, Australia
    • ,
  • Ann K. Goodchild

Australian School of Advanced Medicine, Macquarie University, Sydney, Australia

Received 1 February 2009; received in revised form 15 February 2009; accepted 26 March 2009.

Article Outline

Abstract 

This review considers the role played by neuropeptides which, unlike GABA and glutamate (acting at ligand-gated ion channels), modulate cardiorespiratory reflexes slowly through metabotropic receptors. Our findings reveal that reflexes may be differentially modulated so that depending on which neuropeptide agonist is microinjected into the rostral ventrolateral medulla, differential effects on reflexes are observed. This means that, for example, the mu opioid agonist DAMGO will attenuate the sympathetic baroreflex but not the somatosympathetic reflex. On the other hand, the delta agonist DPDPE attenuates the somatosympathetic reflex but has no effect on baroreflex function. These, and other data with other peptides, suggest that neuropeptides may play a crucial role in the modulation of different adaptive reflexes.

Keywords:  Respiration , Rostral ventrolateral medulla , Sympathetic function

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PII: S1016-3190(09)60019-7

doi:10.1016/S1016-3190(09)60019-7

Tzu Chi Medical Journal
Volume 21, Issue 2 , Pages 99-102, June 2009

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