Tzu Chi Medical Journal
Volume 21, Issue 4 , Pages 302-309, December 2009

Different Effects of Volatile Anesthetics on Cardiovascular Neural Regulation of the Autonomic Nervous System in the Streptozotocin-induced Diabetic Rat

  • Po-Kai Wang

      Affiliations

    • Department of Anesthesiology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    • ,
  • Tzong-Bor Sun

      Affiliations

    • Institute of Physiological and Anatomical Medicine, Tzu Chi University, Hualien, Taiwan
    • Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Kun-Ruey Shieh

      Affiliations

    • Institute of Physiological and Anatomical Medicine, Tzu Chi University, Hualien, Taiwan
    • Institute of Neuroscience, Tzu Chi University, Hualien, Taiwan
    • ,
  • Chia-Ling Lee

      Affiliations

    • Department of Anesthesiology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    • ,
  • Jimmy Ong

      Affiliations

    • Department of Anesthesiology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    • ,
  • Ming-Hwang Shyr

      Affiliations

    • Department of Anesthesiology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    • ,
  • Tsung-Ying Chen

      Affiliations

    • Department of Anesthesiology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    • Graduate Institute of Clinical Medicine, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Anesthesiology, Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien, Taiwan

Received 8 June 2009; received in revised form 22 July 2009; accepted 5 September 2009.

Abstract 

Objective

Inhalation anesthetics increase heart rate (HR) in vivo in both animals and humans but decrease heart rate in isolated hearts. Clinical studies indicate that insulin-dependent diabetes mellitus is associated with alterations in autonomic nervous system control of cardiovascular function. The specific aim of this study was to elucidate the effects of different inhalation anesthetics on cardiovascular autonomic function in diabetic rats.

Materials and Methods

We measured blood pressure variability (BPV) in streptozotocin (STZ, 60 mg/kg, i.p.)-induced diabetic Sprague-Dawley rats and vehicle control groups exposed to different inhalation anesthetics (halothane, desflurane and sevoflurane) and BPV was recorded until the recovery stage. Frequency-domain analysis of telemetric systemic arterial pressure and pulse-pulse interval were applied to quantify the parameters of BPV. High frequency power (HF) was regarded as cardiac vagal modulation. Low frequency power of BPV (BLF) was referred to as vascular sympathetic modulation. Normalized low-frequency power (LF%) of the spectrogram of the RR interval was regarded as cardiac sympathetic modulation.

Results

STZ-induced diabetes was associated with a significant reduction of HR but not consistently with a higher HF among these volatile anesthetics. BLF was significantly decreased at one minimum alveolar concentration (MAC) of desflurane when compared with halothane and sevoflurane in the STZ-induced diabetic group. We found an early recovery of the BLF to awake stage baseline values 30 minutes post-anesthesia for sevoflurane, although it was not significant when compared with the other two anesthetics. However, the LF% significantly recovered to 80% of awake baseline values with desflurane and sevoflurane when compared with halothane 30 minutes post-anesthesia.

Conclusion

The components of sympathetic regulation (BLF and LF%) may be an early sign of hemodynamic recovery to the awake stage during anesthesia in STZ-induced diabetic rats. Our results provide an indication for clinical anesthetic choice in diabetes patients receiving anesthesia.

Keywords:  Blood pressure variability , Diabetes mellitus , Rats , Volatile anesthetics

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PII: S1016-3190(09)60060-4

doi:10.1016/S1016-3190(09)60060-4

Tzu Chi Medical Journal
Volume 21, Issue 4 , Pages 302-309, December 2009

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