Tzu Chi Medical Journal
Volume 21, Issue 4 , Pages 327-330 , December 2009

Recurrent Nasopharyngeal Carcinoma Presenting as a Positron Emission Tomography False-negative Scan

  • Chien Shih

      Affiliations

    • Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • Department of Otolaryngology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan
  • ,
  • Jenq-Yuh Ko

      Affiliations

    • Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
  • ,
  • Cheng-Ping Wang

      Affiliations

    • Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • Department of Otolaryngology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, National Taiwan University Hospital, 7, Chung-Shan South Road, Taipei, Taiwan
  • ,
  • Lai-Lei Ting

      Affiliations

    • Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
  • ,
  • Jong-Kai Hsiao

      Affiliations

    • Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

Received 27 December 2008 ,Revised 7 January 2009 ,Accepted 19 January 2009.

References 

  1. Yu MC , Yuan JM . Epidemiology of nasopharyngeal carcinoma . Semin Cancer Biol . 2002;12:421–429
  2. Hsu MM , Tu SM . Nasopharyngeal carcinoma in Taiwan. Clinical manifestations and results of therapy . Cancer . 1983;52:362–368
  3. Chan AT , Teo PM , Huang DP . Pathogenesis and treatment of nasopharyngeal carcinoma . Semin Oncol . 2004;31:794–801
  4. Chang JT , Ko JY , Hong RL . Recent advances in the treatment of nasopharyngeal carcinoma . J Formos Med Assoc . 2004;103:496–510
  5. Teo PM , Chan AT . Treatment strategy and clinical experience . Semin Cancer Biol . 2002;12:497–504
  6. Hong RL , Ting LL , Ko JY , et al.   Induction chemotherapy with mitomycin, epirubicin, cisplatin, fluorouracil, and leucovorin followed by radiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma . J Clin Oncol . 2001;19:4305–4313
  7. Ng SH , Joseph CT , Chan SC , et al.   Clinical usefulness of F18-FDG PET in nasopharyngeal carcinoma patients with questionable MRI findings for recurrence . J Nucl Med . 2004;45:1669–1676
  8. Yen RF , Hung RL , Pan MH , et al.   18-fluoro-2-deoxyglucose positron emission tomography in detecting residual/recur-rent nasopharyngeal carcinomas and comparison with magnetic resonance imaging . Cancer . 2003;98:283–287
  9. Tsai MH , Shiau YC , Kao CH , Shen YY , Lin CC , Lee CC . Detection of recurrent nasopharyngeal carcinomas with positron emission tomography using 18-fluoro-2-deoxyglucose in patients with indeterminate magnetic resonance imaging findings after radiotherapy . J Cancer Res Clin Oncol . 2002;128:279–282
  10. Kao CH , Shiau YC , Shen YY , Yen RF . Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium-99 m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography. Comparison with 18-fluoro-2-deoxyglucose positron emission tomography . Cancer . 2002;94:1981–1986
  11. Yen RF , Hong RL , Tzen KY , Pan MH , Chen TH . Whole-body 18F-FDG PET in recurrent or metastatic nasopharyngeal carcinoma . J Nucl Med . 2005;46:770–774
  12. Liu SH , Chang JT , Ng SH , Chan SC , Yen TC . False positive fluorine-18 fluorodeoxy-D-glucose positron emission tomography finding caused by osteoradionecrosis in a nasopharyngeal carcinoma patient . Br J Radiol . 2004;77:257–260
  13. Ho CL . Clinical PET imaging: an Asian perspective . Ann Acad Med Singapore . 2004;33:155–165
  14. Lee AW , Sze WM , Au JS , et al.   Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience . Int J Radiat Oncol Biol Phys . 2005;61:1107–1116
  15. Ng SH , Chang JT , Ko SF , Wan YL , Tang LM , Chen WC . MRI in recurrent nasopharyngeal carcinoma . Neuroradiology . 1999;41:855–862
  16. Chong VF , Fan YF . Detection of recurrent nasopharyngeal carcinoma: MR imaging versus CT . Radiology . 1997;202:463–470
  17. Ng SH , Liu HM , Ko SF , Hao SP , Chong VF . Posttreatment imaging of the nasopharynx . Eur J Radiol . 2002;44:82–95
  18. Gong QY , Zheng GL , Zhu HY . MRI differentiation of recurrent nasopharyngeal carcinoma from postradiation fibrosis . Comput Med Imaging Graph . 1991;15:423–429
  19. Hung GU , Tsai SC , Lin WY . Extraordinarily high F-18 FDG uptake caused by radiation necrosis in a patient with nasopharyngeal carcinoma . Clin Nucl Med . 2005;30:558–559
  20. Lee AW , Law SC , Ng SH , et al.   Retrospective analysis of nasopharyngeal carcinoma treated during 1976—1985: late complications following megavoltage irradiation . Br J Radiol . 1992;65:918–928
  21. Lin YS , Jen YM , Lin JC . Radiation-related cranial nerve palsy in patients with nasopharyngeal carcinoma . Cancer . 2002;95:404–409
  22. Li JC , Mayr NA , Yuh WT , Wang JZ , Jiang GL . Cranial nerve involvement in nasopharyngeal carcinoma: response to radiotherapy and its clinical impact . Ann Otol Rhinol Laryngol . 2006;115:340–345
  23. Chang JT , Lin CY , Chen TM , et al.   Nasopharyngeal carcinoma with cranial nerve palsy: the importance of MRI for radiotherapy . Int J Radiat Oncol Biol Phys . 2005;63:1354–1360
  24. Yen RF , Yen MF , Hong RL , Tzen KY , Chien CR , Chen TH . The cost-utility analysis of 18-fluoro-2-deoxyglucose positron emission tomography in the diagnosis of recurrent nasopharyngeal carcinoma . Acad Radiol . 2009;16:54–60
  25. Comoretto M , Balestreri L , Borsatti E , Cimitan M , Franchin G , Lise M . Detection and restaging of residual and/or recurrent nasopharyngeal carcinoma after chemotherapy and radiation therapy: comparison of MR imaging and FDG PET/CT . Radiology . 2008;249:203–211
  26. Chan SC , Ng SH , Chang JT , et al.   Advantages and pitfalls of 18F-fluoro-2-deoxy-D-glucose positron emission tomography in detecting locally residual or recurrent nasopharyngeal carcinoma: comparison with magnetic resonance imaging . Eur J Nucl Med Mol Imaging . 2006;33:1032–1040

PII: S1016-3190(09)60064-1

doi: 10.1016/S1016-3190(09)60064-1

Tzu Chi Medical Journal
Volume 21, Issue 4 , Pages 327-330 , December 2009