Tzu Chi Medical Journal
Volume 21, Issue 4 , Pages 334-338 , December 2009

Late-onset Methemoglobinemia Induced by Metobromuron/metolachlor

  • Bang-Gee Hsu

      Affiliations

    • Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • School of Medicine, Tzu Chi University, Hualien, Taiwan
    • ,
  • Han-Yu Huang

      Affiliations

    • School of Medicine, Tzu Chi University, Hualien, Taiwan
    • Division of Medical Intensive Care Unit, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Division of Medical Intensive Care Unit, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien, Taiwan

Received 18 September 2008 ,Revised 16 October 2008 ,Accepted 11 December 2008.

References 

  1. Watt BE , Proudfoot AT , Bradberry SM , Vale JA . Poisoning due to urea herbicides . Toxicol Rev . 2005;24:161–166
  2. Wikipedia. Metolachlor . Available at http://en.wikipedia.org/wiki/Metolachlor [Date accessed: October 22, 2008]
  3. US Patent 6455471 — Pesticidal Compositions. Available at http://www.patentstorm.us/patents/6455471/description.html [Date accessed: October 22, 2008]
  4. Yang CC , Hwang SF , Chou MM , Deng JF . Metobromuron/metolachlor ingestion with late onset methemoglobinemia in a pregnant woman successfully treated with methylene blue . J Toxicol Clin Toxicol . 1995;33:713–716
  5. Turcant A , Cailleux A , Le Bouil A , Allain P , Harry P , Renault A . Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS, and LC-ESI-MS-MS . J Anal Toxicol . 2000;24:157–164
  6. Price D . Methemoglobinemia . 7th edition. New York: McGraw-Hill; 2002;
  7. Wright RO , Lewander WJ , Woolf AD . Methemoglobinemia: etiology, pharmacology, and clinical management . Ann Emerg Med . 1999;34:646–656
  8. Haymond S , Cariappa R , Eby CS , Scott MG . Laboratory assessment of oxygenation in methemoglobinemia . Clin Chem . 2005;51:434–444
  9. Kueh YK , Chio LF , Guan R . Congenital enzymopenic methaemoglobinaemia . Ann Acad Med Singapore . 1986;15:250–254
  10. Wang Y , Huang C , Wu Y , Lan F , Tang Y , Zhu Z . Molecular mechanism of recessive congenital methemoglobinemia in Chinese pedigrees . Chin Med J . 1999;112:1032–1035
  11. Hall AH , Kulig KW , Rumack BH . Drug-and chemical-induced methaemoglobinaemia. Clinical features and management . Med Toxicol . 1986;1:253–260
  12. Smith RP , Olson MV . Drug-induced methemoglobinemia . Semin Hematol . 1973;10:253–268
  13. Disanto AR , Wagner JG . Pharmacokinetics of highly ionized drugs. II. Methylene blue: absorption, metabolism, and excretion in man and dog after oral administration . J Pharm Sci . 1972;61:1086–1090
  14. Clifton J , Leikin JB . Methylene blue . Am J Ther . 2003;10:289–291
  15. Whitwam JG , Taylor AR , White JM . Potential hazard of methylene blue . Anaesthesia . 1979;34:181–182
  16. Goluboff N , Wheaton R . Methylene blue induced cyanosis and acute hemolytic anemia complicating the treatment of methemoglobinemia . J Pediatr . 1961;58:86–89
  17. Liao YP , Hung DZ , Yang DY . Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia . Vet Hum Toxicol . 2002;44:19–21

PII: S1016-3190(09)60066-5

doi: 10.1016/S1016-3190(09)60066-5

Tzu Chi Medical Journal
Volume 21, Issue 4 , Pages 334-338 , December 2009

Article Tools