Tzu Chi Medical Journal
Volume 19, Issue 3 , Pages 109-114 , September 2007

Basic Pharmacology of Botulinum Toxin in the Lower Urinary Tract

  • Alex Tong-Long Lin

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Urology, School of Medicine, National Yang Ming University, 155, Section 2, Linong Street, Taipei, Taiwan

Received 1 February 2007 ,Revised 9 April 2007 ,Accepted 23 April 2007.

References 

  1. Bonifacino JS , Glick BS . The mechanisms of vesicle budding and fusion . Cell . 2004;116:153–166
  2. Hong W . SNAREs and traffic . Biochim Biophys Acta . 2005;1744:493–517
  3. Dong M , Yeh F , Tepp WH , et al.   SV2 is the protein receptor for botulinum neurotoxin A . Science . 2006;312:592–596
  4. Harper M , Fowler CJ , Dasgupta P . Botulinum toxin and its applications in the lower urinary tract . BJU Int . 2004;93:702–706
  5. Smith CP , Chancellor MB . Emerging role of botulinum toxin in the management of voiding dysfunction . J Urol . 2004;171:2128–2137
  6. Ellies M , Laskawi R , Gotz W , et al.   Immunohistochemical and morphometric investigations of the influence of botulinum toxin on the submandibular gland of the rat . Eur Arch Otorhinolaryngol . 1999;256:148–152
  7. Smith CP , Franks ME , McNeil BK , et al.   Effect of botulinum toxin A on the autonomic nervous system of the rat lower urinary tract . J Urol . 2003;169:1896–1900
  8. Wonnacott S . Inhibition by botulinum toxin of acetylcho-line release from synaptosomes: latency of action and the role of gangliosides . J Neurochem . 1980;34:1567–1573
  9. Shone CC , Melling J . Inhibition of calcium-dependent release of noradrenaline from PC12 cells by botulinum type-A neurotoxin. Long-term effects of the neurotoxin on intact cells . Eur J Biochem . 1992;207:1009–1016
  10. Ashton AC , Dolly JO . Characterization of the inhibitory action of botulinum neurotoxin type A on the release of several transmitters from rat cerebrocortical synaptosomes . J Neurochem . 1988;50:1808–1816
  11. Morris JL , Jobling P , Gibbins IL . Botulinum neurotoxin A attenuates release of norepinephrine but not NPY from vasoconstrictor neurons . Am J Physiol Heart Circ Physiol . 2002;283:H2627–H2635
  12. Durham PL , Cady R , Cady R . Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy . Headache . 2004;44:35–42
  13. Chuang YC , Yoshimura N , Huang CC , et al.   Intravesical botulinum toxin A administration produces analgesia against acetic acid induced bladder pain responses in rats . J Urol . 2004;172:1529–1532
  14. Welch MJ , Purkiss JR , Foster KA . Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins . Toxicon . 2000;38:245–258
  15. Smith CP , Vemulakonda VM , Kiss S , et al.   Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: effect of botulinum toxin A . Neurochem Int . 2005;47:291–297
  16. Wang EC , Lee JM , Ruiz WG , et al.   ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells . J Clin Invest . 2005;115:2412–2422
  17. Morris JL , Jobling P , Gibbins IL . Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons . Am J Physiol Heart Circ Physiol . 2001;281:H2124–H2132
  18. Olgart C , Gustafsson LE , Wiklund NP . Evidence for nonvesicular nitric oxide release evoked by nerve activation . Eur J Neurosci . 2000;12:1303–1309
  19. James AN , Ryan JP , Parkman HP . Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle . Am J Physiol Gastrointest Liver Physiol . 2003;285:G291–G297
  20. Hassan SM , Jennekens FG , Veldman H . Botulinum toxin-induced myopathy in the rat . Brain . 1995;118(Pt 2):533–545
  21. Ma J , Shen J , Lee CA , et al.   Gene expression of nAChR, SNAP-25 and GAP-43 in skeletal muscles following botulinum toxin A injection: a study in rats . J Orthop Res . 2005;23:302–309
  22. Chuang YC , Huang CC , Kang HY , et al.   Novel action of botulinum toxin on the stromal and epithelial components of the prostate gland . J Urol . 2006;175:1158–1163
  23. Liu Z , Tearle AW , Nai Q , et al.   Rapid activity-driven SNARE-dependent trafficking of nicotinic receptors on somatic spines . J Neurosci . 2005;25:1159–1168
  24. Jain S , Tamer SK , Hiran S . Botulinum toxin as therapeutic agent in local hyperhydrosis . J Assoc Physicians India . 2002;50:273–274
  25. Swartling C , Naver H , Lindberg M . Botulinum A toxin improves life quality in severe primary focal hyperhidrosis . Eur J Neurol . 2001;8:247–252
  26. Naumann M , Hofmann U , Bergmann I , et al.   Focal hyper-hidrosis: effective treatment with intracutaneous botulinum toxin . Arch Dermatol . 1998;134:301–304
  27. Jongerius PH , Joosten F , Hoogen FJ , et al.   The treatment of drooling by ultrasound-guided intraglandular injections of botulinum toxin type A into the salivary glands . Laryngoscope . 2003;113:107–111
  28. Porta M , Gamba M , Bertacchi G , et al.   Treatment of sialorrhoea with ultrasound guided botulinum toxin type A injection in patients with neurological disorders . J Neurol Neurosurg Psychiatry . 2001;70:538–540
  29. Nadelhaft I . Cholinergic axons in the rat prostate and neurons in the pelvic ganglion . Brain Res . 2003;989:52–57
  30. Dixon JS , Jen PY , Gosling JA . The distribution of vesicular acetylcholine transporter in the human male genitourinary organs and its co-localization with neuropeptide Y and nitric oxide synthase . Neurourol Urodyn . 2000;19:185–194
  31. Doggweiler R , Zermann DH , Ishigooka M , et al.   Botox-induced prostatic involution . Prostate . 1998;37:44–50
  32. Cui M , Khanijou S , Rubino J , et al.   Subcutaneous administration of botulinum toxin A reduces formalin-induced pain . Pain . 2004;107:125–133
  33. Aoki KR . Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A . Neurotoxicology . 2005;26:785–793
  34. Chuang YC . Intraprostatic capsaicin injection as a novel model for non-bacteria prostatitis . J Urol . 2006; [Abstract]
  35. Scott AB , Suzuki D . Systemic toxicity of botulinum toxin by intramuscular injection in the monkey . Mov Disord . 1988;3:333–335
  36. Herrero BA , Ecklung AE , Streett CS , et al.   Experimental botulism in monkeys–a clinical pathological study . Exp Mol Pathol . 1967;6:84–95
  37. Bakheit AM , Ward CD , McLellan DL . Generalised botulism-like syndrome after intramuscular injections of botulinum toxin type A: a report of two cases . J Neurol Neurosurg Psychiatry . 1997;62:198
  38. Bhatia KP , Munchau A , Thompson PD , et al.   Generalised muscular weakness after botulinum toxin injections for dystonia: a report of three cases . J Neurol Neurosurg Psychiatry . 1999;67:90–93
  39. Wyndaele JJ , Van Dromme SA . Muscular weakness as side effect of botulinum toxin injection for neurogenic detrusor overactivity . Spinal Cord . 2002;40:599–600
  40. Wilson F . Botulinum toxin-A risks overcome by proper technique . Cosmetic Surg Times . 2001;12
  41. Claus D , Druschky A , Erbguth F . Botulinum toxin: influence on respiratory heart rate variation . Mov Disord . 1995;10:574–579
  42. Nebe A , Schelosky L , Wissel J , et al.   No effects on heart-rate variability and cardiovascular reflex tests after botulinum toxin treatment of cervical dystonia . Mov Disord . 1996;11:337–339
  43. Schnider P , Brichta A , Schmied M , et al.   Gallbladder dysfunction induced by botulinum A toxin . Lancet . 1993;342:811–812
  44. Dressler D , Benecke R . Autonomic side effects of botulinum toxin type B treatment of cervical dystonia and hyperhidrosis . Eur Neurol . 2003;49:34–38
  45. Dykstra DD , Sidi AA . Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a double-blind study . Arch Phys Med Rehabil . 1990;71:24–26
  46. Ghei M , Maraj BH , Miller R , et al.   Effects of botulinum toxin B on refractory detrusor overactivity: a randomized, double-blind, placebo controlled, crossover trial . J Urol . 2005;174:1873–1877
  47. Brin MF . Botulinum toxin: chemistry, pharmacology, toxicity, and immunology . Muscle Nerve . 1997;(Suppl 6):S146–S168

PII: S1016-3190(10)60002-X

doi: 10.1016/S1016-3190(10)60002-X

Tzu Chi Medical Journal
Volume 19, Issue 3 , Pages 109-114 , September 2007