Tzu Chi Medical Journal
Volume 19, Issue 3 , Pages 139-144, September 2007

Arterial Stiffness in Hemodialysis Patients

  • Wen-Tien Wu

      Affiliations

    • Department of Orthopedics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Ru-Ping Lee

      Affiliations

    • Department of Nursing, Tzu Chi University, Hualien, Taiwan
    • ,
  • Chih-Hsien Wang

      Affiliations

    • Department of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Te-Chao Fang

      Affiliations

    • Department of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Medicine, Tzu Chi University, Hualien, Taiwan
    • ,
  • Bang-Gee Hsu

      Affiliations

    • Department of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Medicine, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Nephrology, Buddhist Tzu Chi General Hospital, 707, Chung Yang Road, Section 3, Hualien, Taiwan

Received 26 February 2007; received in revised form 16 March 2007; accepted 29 March 2007.

Article Outline

Abstract 

Objectives

Increased arterial stiffness is an independent predictor of death from cardiovascular disease, and cardiovascular disease is the leading cause of death among patients with end-stage renal disease. The aim of this study was to compare arterial stiffness in hemodialysis patients.

Patients and Methods

Serum samples were taken from 42 hemodialy-sis patients with the same high flux artificial kidney. Brachial-ankle pulse wave velocity (baPWV) was measured in the right or left brachial artery to the ankle segments that did not have arteriovenous fistula using an automatic pulse wave analyzer. Plasma adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body fat mass was determined using bioelectrical impedance analysis.

Results

Arterial stiffness was higher in hemodialysis patients (85.7%). Age (p = 0.018), systolic blood pressure (p < 0.001) and fasting glucose (p = 0.007) were higher, and hematocrit (p = 0.016) was lower in hemo-dialysis patients with arterial stiffness. Plasma homocystine (p = 0.899), adiponectin (p = 0.204), C-reactive protein (p = 0.276), body fat mass (p = 0.756), total cholesterol (p = 0.607), triglyceride (p = 0.737), calcium (p = 0.698) and phosphorous (p = 0.629) metabolism were not associated with arterial stiffness in hemodialysis patients. Multivariate forward step-wise linear regression analysis of arterial stiffness showed that systolic blood pressure and age were independent predictors of arterial stiffness in hemodialysis patients and explained 45.8% of the variance in patients with arterial stiffness (R2 = 0.458).

Conclusion

The incidence of arterial stiffness was higher in hemodialy-sis patients. Systolic blood pressure and age were independent predictors of arterial stiffness in hemodialysis patients.

Keywords:  Arterial stiffness , Hemodialysis , Pulse wave velocity

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PII: S1016-3190(10)60006-7

doi:10.1016/S1016-3190(10)60006-7

Tzu Chi Medical Journal
Volume 19, Issue 3 , Pages 139-144, September 2007

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