Tzu Chi Medical Journal
Volume 19, Issue 4 , Pages 220-225 , December 2007

Clinical Experiences with Recombinant Activated Factor VII for Managing Uncontrolled Hemorrhage in Non-Hemophilic Patients

  • Chi-Cheng Li

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Ji-Hung Wang

      Affiliations

    • Department of Cardiovascular Disease, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
  • ,
  • Yen-Ta Huang

      Affiliations

    • Department of Medical Intensive Care Unit, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
  • ,
  • Han-Yu Huang

      Affiliations

    • Department of Medical Intensive Care Unit, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
  • ,
  • Tso-Fu Wang

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Sung-Chao Chu

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Chao-Yuan Yao

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Yi-Feng Wu

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Szu-Chin Li

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Kuan-Po Huang

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Wei-Han Huang

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
  • ,
  • Ming-Ching Shen

      Affiliations

    • Department of Oncology/Hematology, Changhua Christian Hospital, Changhua, Taiwan
  • ,
  • Ruey-Ho Kao

      Affiliations

    • Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Oncology, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Oncology/Hematology, Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien, Taiwan

Received 20 April 2007 ,Revised 8 May 2007 ,Accepted 13 June 2007.

References 

  1. Hedner U , Glazer S , Pingel K , et al.   Successful use of recombinant VIIa in patient with severe haemophilia A during synovectomy . Lancet . 1988;2:1193
  2. Ingerslev J . Efficacy and safety of recombinant factor VIIa in the prophylaxis of bleeding in various surgical procedures in hemophilic patients with factor VIII and factor IX inhibitors . Semin Throm Haemost . 2000;26:425–432
  3. Lusher J , Ingerslev J , Roberts H , Hedner U . Clinical experience with recombinant factor VIIa . Blood Coagul Fibrinolysis . 1998;9:119–128
  4. Baudo F , De Cataldo F , Gaidano G . Treatment of acquired factor VIII inhibitor with recombinant activated factor VIIa: data from the Italian registry of acquired hemophilia . Haematologica . 2004;89:759–761
  5. Bauer KA . Treatment of factor VII deficiency with recombinant factor VIIa . Haemostasis . 1996;26(Suppl 1):155–158
  6. Poon MC , D'Oiron R , Von Depka M , et al.   Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann's thrombasthenia: results of an international survey . J Thromb Haemost . 2004;2:1096–1103
  7. Hoffman M . A cell-based model of coagulation and the role of factor VIIa . Blood Rev . 2003;17(Suppl 1):S1–S5
  8. Roberts HR , Monroe DM , Oliver JA , Chang JY , Hoffman M . Newer concepts of blood coagulation . Haemophilia . 1998;4:331–334
  9. Hedner U . NovoSeven as a universal haemostatic agent . Blood Coagul Fibrinolysis . 2000;11(Suppl 1):S107–S111
  10. Bernstein D . Effectiveness of the recombinant factor VIIa in patients with the coagulopathy of advanced Child's B and C cirrhosis . Semin Thromb Hemost . 2000;26:437–438
  11. Hendriks HG , van der Maaten JM , de Wolf J , Waterbolk TW , Slooff MJ , van der Meer J . An effective treatment of severe intractable bleeding after valve repair by one single dose of activated recombinant factor VII . Anesth Analg . 2001;93:287–289
  12. Moscardo F , Perez F , de la Rubia J , et al.   Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII . Br J Haematol . 2001;114:174–176
  13. Vlot AJ , Ton E , Mackaay AJ , Kramer MH , Gaillard CA . Treatment of a severely bleeding patient without preexisting coagulopathy with activated recombinant factor VII . Am J Med . 2000;108:421–423
  14. White B , McHale J , Ravi N , et al.   Successful use of recombinant FVIIa (Novoseven) in the management of intractable post-surgical intra-abdominal haemorrhage . Br J Haematol . 1999;107:677–678
  15. O'Connell NM , Perry DJ , Hodgson AJ , O'Shaughnessy DF , Laffan MA , Smith OP . Recombinant FVIIa in the management of uncontrolled hemorrhage . Transfusion . 2003;43:1711–1716
  16. Vilstrup H , Markiewicz M , Biesma D , et al.   Recombinant activated factor VII in an unselected series of cases with upper gastrointestinal bleeding . Thromb Res . 2006;118:595–601
  17. Manning BJ , Hynes N , Courtney DF , Sultan S . Recombinant factor VIIa in the treatment of intractable bleeding in vascular surgery . Eur J Vasc Endovasc Surg . 2005;30:525–527
  18. Ahonen J , Jokela R . Recombinant factor VIIa for life-threatening post-partum haemorrhage . Br J Anaesth . 2005;94:592–595
  19. Friederich PW , Henny CP , Messelink EJ , et al.   Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomized trial . Lancet . 2003;361:201–205
  20. Mayer SA , Brun NC , Begtrup K , et al.   Recombinant activated factor VII for acute intracerebral hemorrhage . N Engl J Med . 2005;352:777–785
  21. Rizoli SB , Chughtai T . The emerging role of recombinant activated factor VII (rFVIIa) in the treatment of blunt traumatic haemorrhage . Expert Opin Biol Ther . 2006;6:73–81
  22. Bosch J , Thabut D , Bendtsen F , et al.   Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial . Gastroenterology . 2004;127:1123–1130
  23. Kristensen J , Killander A , Hippe E , et al.   Clinical experience with recombinant factor VIIa in patients with thrombocytopenia . Haemostasis . 1996;26(Suppl 1):159–164
  24. Brenner B , Hoffman R , Balashov D , Shutluko E , Culic SD , Nizamoutdinova E . Control of bleeding caused by thrombocytopenia associated with hematologic malignancy: an audit of the clinical use of recombinant activated factor VII . Clin Appl Thromb/Hemost . 2005;11:401–410
  25. Hedner U . Dosing and monitoring NovoSeven treatment . Haemostasis . 1996;26(Suppl 1):102–108
  26. Siddiqui MA , Scott LJ . Recombinant factor VIIa (Eptacog Alfa): a review of its use in congenital or acquired haemophilia and other congenital bleeding disorders . Drugs . 2005;65:1161–1177
  27. Martinowitz U , Michaelson M . Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force . J Thromb Haemost . 2005;3:640–648
  28. Matsumoto T , Shima M , Takeyama M , et al.   The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay . J Thromb Haemost . 2006;4:377–384
  29. Parameswaran R , Shapiro AD , Gill JC , Kessler CM . Dose effect and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: analysis from the Hemophilia and Thrombosis Research Society Registry . Haemophilia . 2005;11:100–106
  30. Abshire T , Kenet G . Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors . J Thromb Haemost . 2004;2:899–909

PII: S1016-3190(10)60019-5

doi: 10.1016/S1016-3190(10)60019-5

Tzu Chi Medical Journal
Volume 19, Issue 4 , Pages 220-225 , December 2007