Tzu Chi Medical Journal
Volume 22, Issue 2 , Pages 106-110, June 2010

Successful Treatment of Two Cases of Invasive Aspergillus Sinusitis With Voriconazole

  • Chen-Hao Li

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • ,
  • Chorng-Jang Lay

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • ,
  • Yu-Huai Ho

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Lih-Shinn Wang

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • School of Medicine, Tzu Chi University, Hualien, Taiwan
    • ,
  • Chun-Lung Wang

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • ,
  • Chen-Chi Tsai

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • School of Medicine, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Division of Infectious Disease, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, 2, Min-Sheng Road, Dalin, Chiayi, Taiwan

Received 31 March 2009; received in revised form 27 April 2009; accepted 2 June 2009.

Abstract 

Aspergillosis is a spectrum of diseases caused by Aspergillus spp., which is a widespread fungus that produces microscopic spores. Immunocompetent people may breathe in numerous Aspergillus every day, yet experience no symptoms. Invasive Aspergillus is relatively rare. There is limited information about the use of voriconazole for the treatment of invasive Aspergillus sinusitis. Here, we present two cases of invasive Aspergillus in elderly female patients with diabetes mellitus. Both patients fully recovered after treatment using surgical debridement and an antifungal regimen that included voriconazole.

Keywords:  Aspergillosis , Sinusitis , Voriconazole

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PII: S1016-3190(10)60050-X

doi:10.1016/S1016-3190(10)60050-X

Tzu Chi Medical Journal
Volume 22, Issue 2 , Pages 106-110, June 2010

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